Aliases: YHR079C, IRE1, ERN1

[SGD] [BioGRID] [GeneDB] [Ensembl] [Entrez Gene]

Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress

Note: On Cytoscape figures, arrows represent only bait-prey directionality, not functional directionality.